The phrase comes from the Neapolitan song Pigliate na pastiglia by Italian singer Renato Carosone, released in the 1950s, where a doctor keeps prescribing a pill for every complaint. The catchy refrain outlived the song and became a common Italian saying for telling someone to calm down. Short clips of the line later circulated on WhatsApp and social media as a ready-made reaction, especially in Italian chats, where sending it is quicker and funnier than typing the same advice during an argument or a moment of panic.