The line is associated with Aldo, Giovanni e Giacomo, the Italian comedy trio of Aldo Baglio, Giovanni Storti and Giacomo Poretti, popular on stage, television and in films since the 1990s. Their catchphrases became part of everyday Italian speech and later circulated widely as short clips in chats and meme edits. This phrase survived because it works without context: the pitying tone is understood even by viewers who do not know the original sketch, and it can be aimed at any exaggerated complaint.
About this sound
Poverino che brutta malattia is a short Italian comedy clip from Aldo, Giovanni e Giacomo, used as a mock sympathetic reaction to minor complaints and mishaps.
The clip captures a line delivered with exaggerated pity in Italian, poverino che brutta malattia, or poor thing, what a horrible illness. The voice drags the sympathy out in a way that sounds caring at first, then clearly sarcastic, as if a tiny problem were a serious diagnosis. That contrast is the joke. Listeners know the speaker is not worried at all, but is teasing someone for complaining, exaggerating or seeking attention. Played over a small mishap, the line instantly turns it into melodrama and makes the moment feel both affectionate and mocking.