Place it immediately after the question on screen, then follow it with a reaction such as Oh My God Wow for surprise or Nelson's Ha-Ha! for mockery, depending on whether the yes is sincere or sarcastic. Keep it as the punchline rather than burying it mid-edit.
About this sound
This six-second clip is a Spanish voice repeating “sí” three times before adding “poh claro que sí,” a colloquial way of saying of course yes. The repetition makes a plain agreement sound eager and emphatic, with a teasing, over-the-top confidence. It feels playful and decisive, perfect for answering a question that hardly needs asking.