The phrase is a piece of blunt Mexican Spanish slang, roughly asking what on earth someone is doing, and the clip circulates online as a short reaction sound rather than as a line from a named film or show. Its appeal comes from that everyday, exasperated tone, which makes it easy to drop into unrelated videos whenever someone acts strangely. Shared through meme soundboards and short-form videos, it has stayed in use because the question works in almost any language context where the frustration is clear from delivery alone.