Place it right after the on-screen question in a reaction edit, then follow it with the awkward crickets sound effect before cutting to the next scene, a confused zoom, or a teammate's delayed response.
About this sound
This 1.2-second voice clip has Polish streamer Rafonix saying 'ty no nie wiem,' roughly well I do not know, in a flat, slightly annoyed tone. It feels funny, lazy and bluntly honest, like a shrug you can hear. The cut comes from a longer rant and keeps only this opening non-answer.