Put it right after the strange reveal in your edit, so the reaction lands on the odd moment itself. Follow it with Bruh when you want disbelief, or with Goofy Ahh Sounds when you want a lighter follow-up after it.
About this sound
This is a short meme clip of just under three seconds built around the drawn-out word esquisitoooo, the Portuguese word for weird, delivered as a playful reaction sound. It gives a funny, awkward feeling, like catching something odd and pointing it out with a grin.