Place it right after the reveal of the messy room or burnt food, then follow it with a fart with reverb for the smell gag and emotional damage for the victim's reaction. Keep the focus on the reaction and let the second sound carry the payoff.
About this sound
This is a short meme clip from Rica Games built around the Portuguese phrase fedor de piru, running just under five seconds. It lands as a quick gross-out gag, the kind of teasing sound that makes a group laugh at a bad smell or an awkward moment. Its humour comes from the blunt, silly insult itself, delivered as a throwaway reaction rather than a setup.