Place it as the closing reaction after the mishap is already clear on screen. Follow a bruh moment with this clip for escalation, or precede it with emotional damage when you want the second hit to carry the scene to its end.
About this sound
An 8.5-second voice clip built around the plaintive line 'Rip my granny why did she die,' delivered like a kid processing loss out loud. The feeling is melodramatically sad but absurdly funny, because the grief sounds huge, sincere and completely over the top for a meme reaction.