Place it at the very end of a failed attempt or argument, after the reaction has peaked, so it closes the scene. Pair it with Nope just before the exit for a double refusal, then follow it with Run Vine as the character leaves the frame.
About this sound
This five-second clip captures Eric Cartman saying “Screw you guys, I’m going home” in his blunt, nasal voice, with childish anger and perfect comic timing. It feels petty, dramatic and funny, turning a small defeat into a theatrical walkout. The line comes from South Park, where it became one of Cartman's most repeated catchphrases.