Put it at the end of a failed explanation, after the Wrong Answer Game Show sting, so the question and the failed reply frame the moment. If the scene needs a slower finish, follow it with the Sad Violin Meme Sound Effect, and save the Ceeday Huh Sound Effect for a later misunderstanding rather than stacking all three together.
About this sound
This is a brief spoken Arabic line, “sadaqni law araf,” meaning roughly “believe me, if I knew.” The voice sounds resigned and a little frustrated, as if the speaker has run out of explanations. That weary, helpless feeling makes it land as a deadpan reply to impossible questions, awkward moments and chaotic threads, even for listeners who do not understand the words.