Put it right after a friend's bold boast in a short edit, then follow it with the Bruh Meme Sound for a reply before the Fail Sound Meme lands the joke.
About this sound
This Spanish-language clip from The Simpsons runs just over four seconds, with Homer Simpson shouting 'vas a morir, Moe' in an exaggerated threatening voice, then stretching the ending into a long, climbing wiiiiii. The change from pretend menace to gleeful silliness feels playful and teasing rather than scary, so it lands as a joke between friends. It comes from the Spanish dub of the show, where Homer addresses Moe Szyslak.