The clip comes from the Saturday Night Live sketch Helping Hands Telethon, broadcast on 7 May 2005 as part of season 30, episode 18, where Will Forte played Andy, a man defined by his alarmed Oh No reaction to unfolding charity disasters. The line worked because Andy kept finding new reasons to panic, and fans later split his reactions into short soundboard clips, including this first of four versions. Its brevity and clear comic panic have kept it useful for reaction videos and edits long after the original broadcast.