Place it at the end of a sketch, after the setup has already made the audience expect trouble. Follow it with a Bruh sound for a deadpan beat, then an Emotional Damage sound to close the joke.
About this sound
This 3-second clip is a set of drawn-out human moans played for comic effect, with each groan stretched just enough to sound deliberately overdone. It feels cheeky and uncomfortable in a funny way, the kind of noise that makes a group laugh because it is clearly not meant to be taken seriously. Use it as a reaction rather than a background sound.