Place it at the end of a back-and-forth exchange, as the final response that closes the argument. Pair it with the Bruh sound first for a slower build, then let this clip finish the scene, or follow it with Emotional Damage when the other side keeps pushing.
About this sound
This is a short, roughly two-and-a-half-second voice clip of a man saying 'man, it don't matter' in a flat, unbothered tone. It lands as a quick brush-off, funny because it sounds completely done with the conversation and unwilling to argue any further. The clipped delivery makes the indifference feel final, like a shrug in audio form.