The Binding of Isaac is an indie roguelike dungeon crawler first released in 2011, following Isaac, a young child who flees into a monster-filled basement. Its distinctive, unsettling audio has long been shared by players on soundboards and in edited gameplay videos, where short cries and screams are reused outside their original context. This baby scream fits that pattern, travelling from in-game moments into memes and reaction edits because it is instantly recognisable, very short and easy to place over unrelated footage for a sudden shock or laugh.