Place it at the end of a setup clip, right before the reaction shot, then follow it with the Bruh sound for a deadpan answer and the Emotional Damage sound when the target finally snaps. Keep it as the interruption, not the punchline, and let the paired reactions carry the joke.
About this sound
This 2.7-second clip is a short, deliberately grating burst made to irritate on contact, with an edge that keeps nagging after it stops. It feels petty, playful and instantly irritating, the kind of noise that makes people groan, laugh and tell you to stop while they are still smiling. Use it sparingly and it lands harder.