This scream is widely associated with Tom from Tom and Jerry, the long-running animated cat-and-mouse series that began as MGM theatrical shorts in 1940 and later became a TV staple. Online, creators pulled the yell out of the cartoon and turned it into a reusable reaction sound for memes, gameplay clips and short-form videos. It stays popular because the delivery is instantly readable even without context: one loud burst can sell pain, fear or absurd overreaction. It is often paired with cartoon slip timing in comedic edits.