Uguu became famous as the signature catchphrase of Ayu Tsukimiya in Kanon, the visual novel adapted into anime in 2002 and again in 2006. Ayu says it whenever she is flustered, disappointed, or trying to complain without sounding angry, and fans clipped the line as a standalone reaction. It spread through forums, Nico Nico, and early meme soundboards alongside other catchphrase clips like Tuturu, becoming shorthand for cute disappointment in anime communities. It remains popular because one syllable instantly signals the character type and mood.