Put it at the end of an argument clip, after the other person makes their worst claim, so it works as the final reply. Set it up with Ah Shit Here We Go Again, then close the exchange with Nope for a second dismissal.
About this sound
This three-second clip is a voice shouting the Mexican Spanish insult 'vete a la verga' and then dissolving into loud, wheezing laughter. It sounds tearful and over-the-top, caught between crying and laughing as the words tumble out. It feels mocking and gleefully dismissive, like a taunt aimed at someone who has just been told off in the most dramatic way possible.