The phrase plays on the long established idiom about having bigger fish to fry, meaning more important matters need attention. Swapping fish for pickles to tickle turns that everyday saying into deliberate nonsense, which is why it circulates as a short meme voice clip rather than a literal quote from a known scene. Online, creators reuse the three second line as a standalone reaction, letting the familiar setup carry the meaning while the strange ending supplies the joke, so it keeps working even without any original context attached.