Put it at the end of a confusing setup, just before the reveal, then follow it with Bruh for a second reaction or Emotional Damage when the confusion turns into a joke about the fallout.
About this sound
This nine-second clip is built around a single spoken 'What', delivered as a flat, disbelieving reaction to something that makes no sense. It lands as pure confusion, the kind of disbelief that makes a strange statement feel even stranger, and it works because the delivery stays simple and direct instead of turning into a longer rant.