This clip comes from The Boondocks, the adult animated television series that first aired in 2005. Short reaction quotes from the show spread widely through reposts, remixes and soundboard uploads because the voice acting is so expressive and instantly recognizable. Online, this specific line is often used like you what or a verbal record scratch whenever someone says something disrespectful, unbelievable or way too bold. It stays popular because it delivers confrontation in just a few seconds and fits reaction memes, gaming edits and chat videos.