Courage the Cowardly Dog aired on Cartoon Network from 1999 to 2002, created by John R. Dilworth and set in the town of Nowhere, Kansas. Courage, voiced by Marty Grabstein, spent most episodes terrified by monsters, aliens and strange visitors threatening Muriel and Eustace Bagge. His screaming and panicked babbling became the show's signature joke, so short clips of his meltdowns were later shared as reaction sounds on YouTube, TikTok and meme edits, where they still stand in for anyone feeling overwhelmed.