What's in the canister comes from Tom Clancy's Rainbow Six Siege, Ubisoft's tactical shooter released in 2015, where Smoke is a British defender whose special gadget is a remote gas grenade filled with toxic smoke. The line plays on curiosity about that gadget and became a quotable shorthand among Siege players for Smoke mains and gas plays. Shared as a short clip outside matches, it now works as a standalone tease for any unknown container, keeping the joke alive even for viewers who have never played as the operator themselves in game.