The phrase comes from Saturday Night Live's recurring sketch What Up with That, which premiered in 2009 with Kenan Thompson as host Diondre Cole. Cole would sing and dance through interviews, repeatedly returning to the catchy theme and its title line. Clips and quotes from the sketch spread widely online, and the shortened audio became a standalone reaction sound. Its musical delivery and instantly recognisable wording kept it in use for memes, edits, and comment-style reactions long after the original sketches aired on television.