Place it as the punchline reply right after a tired or thirsty moment on screen, then follow it with a quick reaction sound for the response shot. Keep it after the setup line and before the next scene change so the reminder closes the beat.
About this sound
A short voice clip of a man saying 'Ya gotta hydrate, dude' in a casual, laid-back tone, lasting just under four seconds. It feels funny and lightly nagging, like a friendly call-out that turns a basic water reminder into a joke between friends.