The line comes from the Futurama episode Godfellas, first aired in 2002, where Bender is lost in space and meets a vast cosmic entity voiced as God. After Bender recounts trying to rule a tiny civilization living on his body, God replies with gentle approval followed by the blunt observation that everyone died. Clips and quotes from the scene spread across forums and meme pages, and the audio became a shorthand reaction for well-intentioned efforts that end in total failure, which is why it still circulates today.