Place it at the end of a failed explanation, after the Wrong Answer Game Show sting, so the praise lands as the punchline. Follow it with Nelson's Ha-Ha! for a sharper laugh, and keep the sequence short so the joke stays on the person who stated the obvious.
About this sound
This is a short spoken reaction clip built around the line 'You're the smartest in the room,' lasting just under six seconds. The delivery is pointed and mock-admiring, turning a compliment into a tease for someone who has just said something obvious. It lands as wry and slightly cutting, the kind of praise that makes the room laugh at the speaker rather than with them.