The exact origin of 'Nuffin Tew Yew' is undocumented, and it appears to be a user-uploaded soundboard clip rather than a line from a known film, show or song. Its charm is the exaggerated phonetic spelling, which captures how the phrase sounds when said with a thick, cheeky accent. It circulates as a reaction meme on short-form video and soundboard communities, where creators use it to brush off questions or flex a playful attitude. Its staying power comes from that universal, lighthearted dismissiveness.