This sound comes from The Boondocks, the animated television series that first aired in 2005. Short reaction clips from the show spread widely in meme culture because the voice acting and timing fit edits built around shock, offense and disbelief. Online, this quote is often used like a verbal double take, similar to a bruh reaction, especially in short videos, gaming clips and caption memes. Its staying power comes from how quickly it communicates a strong response without needing any setup beyond the line that comes before it.