Place it at the peak of a reaction sequence, right after the surprising reveal and before the response. Follow it with Emotional Damage for the fallout, then Oh My God Meme for disbelief, keeping the sequence short so each reaction lands in turn.
About this sound
This 18-second clip captures Busta Rhymes letting out one long, rising wiiiiiiii that stretches far beyond a normal reaction. It feels gleefully over the top, like someone has just heard something so absurd that only a drawn-out shout will do. The exaggerated delivery makes it funny and instantly recognisable as a meme reaction for wild, unbelievable moments.