The sound comes from Mortal Kombat: Deadly Alliance, the 2002 fighting game that rebooted the series for PlayStation 2, GameCube and Xbox. Male fighter pain and death screams were a staple of Mortal Kombat voice work, and short clips like this were later ripped and shared on soundboards. It has survived as a generic gaming scream because it is brief, recognisable to fighting game fans, and flexible enough to fit any sudden defeat or shock moment in memes and edits.