Place it at the reveal point of a failed play, after building tension, then follow it with Nelson's ha-ha for a mocking reply from the other side. A sudden suspense sting just before the reveal works well, letting this clip carry the reaction while the follow-up carries the teasing.
About this sound
A short 2-second voice clip of NateWantsToBattle shouting 'God is mocking me' in exasperation during a playthrough. It feels theatrically frustrated and funny, like bad luck has become personal rather than random. The clip is taken from his Black 2 Randomizer Episode 32, where the line lands as a reaction to an unlucky in-game turn.