The line comes from the 1980 comedy Airplane, where Dr. Rumack, played by Leslie Nielsen, repeatedly pops into the cockpit to wish the crew good luck. The running gag builds because he returns with the exact same serious delivery at increasingly dangerous moments. Nielsen's shift from dramatic roles to deadpan comedy helped make the scene iconic. The quote later spread as a reaction clip and image macro online, used whenever someone faces a task they are clearly not ready for, with the polite encouragement only adding pressure.