Place it in the middle of a reaction edit, just after the opening line lands, and let it carry the joke before the cut. Follow it with the Vine Boom Sound for a sharper payoff, or open with the Anime Wow Sound and let this clip answer it as the second beat.
About this sound
This is a 15-second repeated vocal effect built around a short, guttural 'gug' sound, delivered again and again with a loose, uneven rhythm. It feels daft and infectious, like a friend making a noise just to break the tension and get a laugh, without needing any words at all.