Place it as the immediate reaction beat right after the reveal or line it answers. For a stacked response, follow it with Oh My God Wow for a bigger group reaction, or precede it with Eww Brother Eww when the moment needs disapproval first.
About this sound
This is a short vocal clip, about three seconds long, built around one stretched-out shout of 'guurl.' It lands as sassy and playfully shocked, the kind of exaggerated callout that turns surprise or disbelief into a joke. The single drawn-out word carries the whole reaction without any extra lines.