Put it at the end of a setup about a friend acting suspiciously relaxed, then follow it with the Bruh sound for the group's reaction and the Emotional Damage sound when the joke turns on the person who brought it up.
About this sound
This is a short Spanish-language clip of Capusoto talking about faso, delivered in his dry, deadpan comic style over about five seconds. It lands as a knowing, cheeky aside, funny because it sounds like a casual confession dropped into ordinary conversation. The moment comes from Capusoto's comedy, where the slang and the straight-faced delivery do most of the work.