The line comes from Good Mythical Morning, the long-running show hosted by Rhett McLaughlin and Link Neal, in a segment where Link straightens Rhett's hair. The moment works because it is unscripted in feel: Rhett is not playing a character, he is reacting in real time to having his hair pulled and heated. Short clips from the show are often lifted for soundboards because the hosts' banter is easy to reuse out of context, and this one survives as a compact admission of sensitivity that fits hair, barber and makeover videos without needing any setup.
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Rhett from Good Mythical Morning admits he is tender-headed while Link straightens his hair, a funny reaction clip for hair, pain and grooming moments.
In this short clip, Rhett McLaughlin says the line in a pained, self-deprecating drawl while Link Neal works through his hair with a straightener. His voice rises a little on tender-headed, then settles into a resigned, matter-of-fact ok, as if he is warning Link and apologising in advance for flinching. It sounds casual and conversational rather than performed, which is why it lands as comedy: the pain is real, the complaint is gentle, and the friendship between the two hosts does the rest. Listeners recognise the moment without seeing the straightener, because Rhett's tone says everything about sensitive scalps and well-meaning friends.