Put it at the end of a reveal sequence, after the embarrassing moment is fully visible, then follow it with Bruh for a second reaction or Emotional Damage when the embarrassment is personal, and save Oh My God for the biggest reaction earlier in the edit.
About this sound
This Hindi voice clip delivers the line Maine Itna Dekha, meaning I have seen so much, in a tired, exasperated delivery that gives the reaction time to land. It lands as weary disbelief and mock wisdom, perfect for reacting to something ridiculous, shameless or painfully familiar without saying anything more.