America's Most Blunted appears on Madvillainy, the 2004 album by Madvillain, the collaboration between rapper MF DOOM and producer Madlib. The track became a cult favorite for its hazy production and DOOM's off kilter wordplay, and short excerpts later circulated widely on meme pages and soundboards. As DOOM's reputation grew after his death in 2020, clips from the album found new audiences online who had never heard the full record, with this marijuana moment becoming a shorthand reference among fans.