Place it at the end of a dramatic setup, after the exaggeration peaks, so it acts as the final dismissal. Pair it before the Bruh Sound Effect for a double reaction, or follow it with the Emotional Damage Meme Sound when the dismissal itself needs a bigger payoff.
About this sound
This is a two-second spoken clip in Brazilian Portuguese, with one flat, unimpressed voice saying nobody cares, you know, over no music or background noise. It feels blunt and funny, like a shrug that cuts a dramatic story short and makes the speaker seem instantly bored. It comes from Brazilian internet humour and is credited to the Menes Suecos page.