Place it right after the rambling line it answers, as a direct reply in the edit, then follow it with Oh My God Wow for the reaction or No No Wait Wait when the speaker tries to start again.
About this sound
A short, sharp Ninja vocal clip lasting about 3.7 seconds, built around a strained, drawn-out groan that snaps into the words shut your mouth. The delivery sounds impatient and fed up, like someone losing patience and cutting a rambling speaker off in one breath. It lands as a blunt, comic shut-down rather than a calm reply, making it easy to recognise even without any picture.