Put it at the end of a short edit, after the bad decision or reveal has played out, so it works as the closing verdict. Open with the Bruh sound to build the setup, then follow this clip with Emotional Damage to stretch the fallout into a second joke.
About this sound
A young male voice delivers a short, exasperated reaction in two beats, stretching out 'oh my god bruh' before snapping into a firm 'oh hell nah'. It sounds weary and incredulous rather than furious, like a final refusal after seeing something too absurd to accept. The clip circulated widely as a reaction sound in the early 2020s.