Based on the published source info for this clip, it comes from Uncharted. Online, short voice reactions from action games often spread because they fit quick edits where a character or player sees trouble coming but cannot stop it. This one stays popular because the repeated “oh no” is instantly understandable even without context, and its very short length makes it easy to drop into TikTok-style videos, stream highlights and meme compilations. It fills a similar reaction role to sounds like nope when a scene turns bad fast.