Place it at the very end of a short edit as the final reaction beat, after the visual gag resolves. For a dumber sequence, lead in with the Doge Bonk Sound Effect on the hit, let this clip answer it, then close with the Wet Fart Sound Effect only if the scene stays cartoonish.
About this sound
This is a short 1.3-second burst of Peter Griffin laughing, delivered in his nasal, rolling cartoon voice. It feels smug, silly and gleefully out of control, like someone cracking up at their own bad joke. The clip comes from Family Guy, the animated series created by Seth MacFarlane where Peter is the main character.