Professor Farnsworth is the elderly scientist and founder of Planet Express in Futurama, the animated science-fiction sitcom created by Matt Groening that first aired in 1999. His confused, hard-of-hearing manner became a running joke throughout the series, and short lines like this one were later lifted for soundboards and meme edits. Because the delivery is instantly recognisable even without context, creators keep using it as a shorthand for bafflement, especially when an older character, a scientist, or a nonsensical plan is involved.