Put it at the end of a rant or complaint clip as the final reply, after Ah Shit Here We Go Again sets up the situation, then follow it with awkward crickets while the other person reacts on screen.
About this sound
This is a short Italian spoken line, lasting about 1.8 seconds, in which a voice delivers the phrase 'Questo me ne sbatto il cazzo' with flat, unbothered emphasis. It feels rude, defiant and funny, like a shrug turned into words for someone who has stopped listening. It works as a blunt brush-off for unwanted advice, drama or a demand.