The Reaper horn comes from the Mass Effect series, where the Reapers are colossal synthetic beings tied to the games' most threatening moments. Fans especially associate this sound with the series' darkest scenes because its deep, unnatural call instantly signals danger on a massive scale. Over time, it spread through gaming edits, reaction videos, and meme compilations as an audio cue for unstoppable force, incoming doom, or a threat far bigger than the people on screen.