Place it as the setup line in a short skit, then cut straight to Bruh for the reaction before the joke cools. For a bigger overreaction, follow it with Emotional Damage Meme Sound instead, letting that second clip carry the punchline while this one stays the question.
About this sound
This is an 11-second Russian spoken clip built around a dry question to Romanenko about whether he knows a symptom, delivered in a calm, clinical tone that makes the setup feel stranger as it goes on. It lands as teasing disbelief, the kind of line that makes a wild claim sound like a medical case, and it works best when the listener knows the joke is coming from nowhere.