"Serenity now" comes from the sitcom Seinfeld, where Frank Costanza uses it as a supposed relaxation mantra. The line became one of the show's most quoted bits because the delivery is so aggressive that it defeats the whole idea of staying calm. Online, it spread through reaction clips, meme compilations, and soundboard buttons for moments of stress or comic overreaction. It still works well because the joke is instantly recognizable even in a very short edit.